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Abnormal cellular interactions, lymphedema distiachiasis

PostPosted: Wed Jun 21, 2006 6:54 pm
by patoco
Abnormal cellular interactions, lymphedema distiachiasis

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Abnormal cellular interactions, lymphedema distiachiasis

Abnormal cellular interactions lay the foundation for lymphedema-distichiasis - Lymphedema

NewsRxAngiogenesis via NewsEdge Corporation : 2004 NOV 12 - ( & -- Abnormal cellular interactions lay the foundation for lymphedema-distichiasis.

According to a study from Finland, lymphatic vessels are essential for the removal of interstitial fluid and prevention of tissue edema. Lymphatic capillaries lack associated mural cells, and collecting lymphatic vessels have valves, which prevent lymph backflow. In lymphedema-distichiasis (LD), lymphatic vessel function fails because of mutations affecting the forkhead transcription factor FOXC2.

We report that Foxc2-/- mice show abnormal lymphatic vascular patterning, increased pericyte investment of lymphatic vessels, agenesis of valves and lymphatic dysfunction, stated T.V. Petrova and colleagues, Biomedicum Helsinki, Molecular/Cancer Biology Laboratory.

"In addition, an abnormally large proportion of skin lymphatic vessels was covered with smooth muscle cells in individuals with LD and in mice heterozygous for Foxc2 and for the gene encoding lymphatic endothelial receptor, Vegfr3 (also known as Flt4).

Our data show that Foxc2 is essential for the morphogenesis of lymphatic valves and the establishment of a pericyte-free lymphatic capillary network and that it cooperates with Vegfr3 in the latter process. Our results indicate that an abnormal interaction between the lymphatic endothelial cells and pericytes, as well as valve defects, underlie the pathogenesis of LD, scientists concluded.

Petrova and colleagues published the results of their research in Nature Medicine (Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis. Nature Med, 2004;10(9):974-981).

For additional information, contact K. Alitalo, Biomedicum Helsinki, Molecular Cancer Biology Laboratory, Haartmaninkatu 8, POB 63, Helsinki 00014, Finland.

The publisher of the journal Nature Medicine can be contacted at: Nature Publishing Group, 345 Park Avenue South, New York, NY 10010-1707, USA.

The information in this article comes under the major subject areas of Angiology, Genomics and Genetics, and Lymphedema.

This article was prepared by Angiogenesis Weekly editors from staff and other reports. Copyright 2004, Angiogenesis Weekly via & .end (paragraph)<<NewsRxAngiogenesis -- 11/12/04, p. 17>>.